Good day! We're thankful for two consecutive weeks of chemotherapy. I'm sure that's not often said. We're here. Based on our lab results, the two weeks on, one week off, seems to be best. The nausea picked up this week. We've added some additional medications to the mix to help including steroids. Amy's self restraint has been incredible. Saturday morning after three hard hours of sleeping, she was up and going at 1 am. Doom scrolling, checking out podcasts, picking up around the house, and most importantly practicing self restraint trying not to wake up Daniel & Libbie. We've got a pretty easy week ahead. Learning to balance the nausea, continuing to dial in the long acting octreotide with some daily doses, and preparing to head to Little Rock to celebrate her father in love's 80th Birthday. Did you know that Amy's favorite Spring time things are Easter & Tulips? She really appreciated the outpouring of love this week from her friends including a wonderful dinner brought over shared together. None of you have asked how Amy spends her Friday nights, we thought we'd share it with you. She's prepping those daily meds for the week ahead.

Good evening, It's been a tough week around the LeSieur household never so thankful for a weekend more than this last one. We've (I've) mentioned and talked about the physical side of our progress but not the mental side. It's just as important. One of the unique challenges with our treatment is that we don't have a chance to measure the progress more often. Amy takes the punches of side effects of her drugs but doesn't know how her body is absorbing or using the chemotherapy until the end of eight weeks (regiment). When your body can't take anymore chemo, because the blood tests aren't at a safe level, it becomes really discouraging. It's easy to fall into mental rabbit hole thinking that it's not working. Well, we rode that roller coaster this week. Then by Friday, her labs were great. And we were back in the chair ready for more. And as expected, the side effects were in full force on Sunday. We expected those, and we'll be out of bed again soon. Nothing new this week, fluids, massage, some work, and prayers for strong blood work to take our next round of therapy on Friday. While I've enjoyed our text messages, some of you joined us recently. And have asked for the story and to know more about her journey. I've built this website for you (and her). I hope this helps catch everyone up!

Feb 23rd Good evening! We've completed two thirds of our new chemotherapy regiment before the lab results got us this week. This week, our platelet counts dropped dramatically; so we had to postpone our treatment to bring those levels up. We are working with our oncologists to make sure that we're still on for our MD Anderson visit at the end of the March. This week's appointments are pretty easy... fluids on Monday, pain management on Wednesday and we'll be reaching out MD Anderson about keeping our chemo schedule as close to plan as possible. So, no chemo, no problemo. Amy was able to getaway this weekend with her girlfriends. They went to Springfield, Mo to see Jerry Seinfeld. I did hear that there are some extremely impressive french fries in Springfield. Many thanks to Lisa, Candice and Carla for the roadtrip! We're consistently overwhelmed with the love and support, and couldn't be more thankful and appreciative. I've heard that some of the new members would like to know more about our journey. I'm diligently working on a website for you. It should be ready soon. Feb 16th Good evening! We're going to keep it brief tonight. We've improved our recovery on the new chemo regiment, little more sleep on Sunday mornings, and more consistent hydration on Saturday's have helped tremendously. Our next big step is the biliary stent procedure. We'll knock that out tomorrow morning, and should be well recovered in a couple of days. Because I asked, and you asked, our favorite Super Bowl commercial was the Pringles Mustache commercial. All in all, we've had a balanced week. A warm bowl of gumbo from Rebecca, fancy ramen noodles, and lots of baby time with Fitz, and the family. –Thank you so much for the prayers and support. This week, we ask that you pray for classmate of Daniel's who has led us through his pancreatic journey. He's been battling almost a year; he's making the choice on whether or not to continue his treatment. Sharing the vibes, energy, and prayerful support through everyone's journey through this. Feb 9th Good Afternoon, Go, Chiefs! Being Super Bowl Sunday, we're getting ready for the big game. Our new chemo regiment was easier on the administration, but harder on the side effects. While these side effects are different such as cold/flu symptoms, fever, body, muscle and joint aches, they've kept our girl mildly uncomfortable on Saturday and bedridden today. She did have a strong week though. She was chipping away at what she needed the most, a fresh haircut with the girls, tacos with Laura, chemo and lunch therapy with Paula, and few days of pampering with her Parents-in-Love. And a thank you to Liz for helping us not worry about dinner last week, or this week. We're learning how to manage the new side effects. We've got fun weekends ahead of us. We don't want to miss anything. Go, Eagles! If you know Amy, she doesn't have a team. She's watching today for violent hits, long runs, one handed catches, ankles and knees that bend in non-natural directions and the commercials. Please text us and let us know what your favorite commercial was. Love D&A Feb 3rd Good evening! Amy is back home from MD Anderson and ready to start round #5 of chemo in the morning. It was an emotional weekend reviewing her latest CT and labs. We're focusing on the next steps only. The good news: The tumor is still localized to the pancreas, and we're already ahead of an expected bile duct blockage by scheduling a stent before jaundice or fevers set in. The tough news: The tumor is now non-resectable due to its impact on the SMV, superior mesenteric vein. The plan: Amy starts a new chemo regimen tomorrow-weekly infusions with two new meds. The upside? Better results for others in her situation, and a break from the GI issues. Hello, constipation! There were fist bumps and laughs about hearing the news. A huge thank you to Jeff and Sheila Little for opening their home to us in Houston. Your love, support, and prayers mean the world. There's still a lot to process; if you have questions, text us, and we'll do our best to respond. Feb 2nd Good evening! Just a reminder that we'll send out a more thorough update after our MD Anderson appointments tomorrow. In the meantime, does anyone know if it's too early for Easter jokes?

Jan 3rd Good afternoon, This week, Amy ventured out to spend New Year's Eve with Staci and the girls. Let's just say this year's New Year nausea was not due to alcohol. The chemotherapy felt like the therapy nightmares that we've heard about, side effects were nausea and vomiting. Twenty-four hours off the pump, Amy's moving around 'cautiously' focusing on the 'rest & digest' medicines and doing some around the house activities. I have a hunch that Spring Cleaning maybe coming early. We're looking forward to a restful weekend of recovery. Upcoming activities ... - Jan 17th & 18th for some Vitamin F (Fitz), - Jan 20th - Chemo #4 - Jan 30th - MD Anderson followup with Surgical Oncologist and CT scan.Just a reminder that this phone number is for our updates. Daniel still has his 509 number. Jan 12th We're feeling strong heading into a big week. It's been almost 10 days since our last chemo infusion. Amy's appetite for Ruffles and Grillo's pickles has come to life. She's also been enjoying some ice and colder items, along with some yellow cheese dip & chile relleno from Maria's. We were excited to leave the house for a date and knock out some to-do's in preparation for our upcoming weeks. This week will be super busy. An early Monday of doctor's appointments and afternoon business meetings. That's right, our girl has been working! She's been meeting with her leadership team making sure 2025 is off to a great start, and her inbox is manageable. Maybe a couple of infusions of vitamins and water to keep her potassium and spirits up. Then we're off to Dallas on Thursday to spend some time with Fitz and the family. He can't wait to tell us all about his first big day in the snow. Then we're heading back to NWA to crush Chemo infusion #4, and back to Texas for our checkup with MD Anderson. Jan 19th Good evening! We're so thankful for an easy weekend in Dallas with Fitz and the family. We really appreciated the extra time Jasmine & Billy allowed us to have with Fitz, babysitting and relaxing. On a brighter side, there's nothing better than being able to handle cold items such as scoops of nutter butter and banana cream ice cream on a cool 40 degree evening. We start the week with doctor's appointment and chemotherapy infusions at 8am🙄. Amy couldn't be more upset that the coldest days of the year are during her chemo week. Please don't mention it. 😉 Then on Wednesday, we'll remove the lemon (portable chemo infusion). Fluids and vitamins the rest of the week. Amy's so thankful for your prayers, vibes and support. She's encouraged daily by them. Jan 26th Did you know that 33 is Amy's favorite number? So, let's use it in some sentences… There's a 33% chance that she didn't return your text messages this week. She's working on that. The average temperature for the majority of last week was less than 33 degrees. And excitedly, we're so thankful for your love, prayers and support as we completed the first 33% of her chemotherapy treatments. As mentioned, the bitter cold temps in NWA didn't help our girl through her chemotherapy this week. But we made it. All in all, we're feeling better excited for our return to MD Anderson. Next weekend, we'll do all of the fun things Texas Medical Center & MDA has to offer like labs, CT, and doctors' visits. Our goals are to better understand the condition of the tumor, impact of the chemo, continue our education and understanding to help us prepare for the whipple procedure. Our highlight of the week was a big Saturday of antiquing and thrifting in Harrison & Alpena, followed by a long overdue dinner of laughs with friends. Love and Thanks, D&A

Dec 30th Good afternoon, We hope that everyone had a wonderful Christmas with family & friends. Amy kicked hers off with a colonoscopy to remove a blockage, a completely successful procedure and evaluation by her GI physician. We'll kick off the New Year with chemotherapy tomorrow, and two more sessions this month before we return to MD Anderson. Over the next few months, we'll be improving our diets and activity levels to help prepare for our whipple procedure. You may have noticed that Daniel geeked out, it's easier to keep everyone up to date for us. We hope you'll stay with us on this journey.